首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   9154篇
  免费   912篇
  国内免费   1601篇
  2024年   14篇
  2023年   147篇
  2022年   187篇
  2021年   474篇
  2020年   397篇
  2019年   499篇
  2018年   485篇
  2017年   348篇
  2016年   412篇
  2015年   708篇
  2014年   758篇
  2013年   753篇
  2012年   962篇
  2011年   869篇
  2010年   558篇
  2009年   525篇
  2008年   602篇
  2007年   535篇
  2006年   447篇
  2005年   391篇
  2004年   333篇
  2003年   284篇
  2002年   217篇
  2001年   102篇
  2000年   120篇
  1999年   106篇
  1998年   76篇
  1997年   85篇
  1996年   63篇
  1995年   49篇
  1994年   35篇
  1993年   22篇
  1992年   17篇
  1991年   6篇
  1990年   12篇
  1989年   3篇
  1988年   6篇
  1987年   9篇
  1985年   8篇
  1984年   6篇
  1983年   4篇
  1982年   12篇
  1976年   2篇
  1974年   3篇
  1973年   2篇
  1965年   1篇
  1963年   1篇
  1959年   1篇
  1950年   5篇
  1911年   1篇
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
1.
2.
3.
MLK-3 kinase is a widely expressed serine/ threonine kinase that bears multiple protein interaction domains and regulates signals mediated by the stress-responsive pathway. Thus, MLK-3 signaling affects numerous cellular processes, raising the possibility that MLK-3 might play a role in oncogenesis. In this report, we describe the fine mapping of the MLK-3 gene within the 11q13.1 chromosomal region. By integrating data from somatic cell hybrids and double color fluorescence in situ hybridization on metaphase chromosomes and DNA fibers, MLK-3 has been assigned approximately 1 Mb telomeric of PYGM, close to the D11S546 locus. Since the MEN1 susceptibility locus is also located within the 11q13.1 region, we have carried out Southern and Northern blot analyses, as well as protein truncation assays to establish whether abnormalities in MLK-3 lead to the development of this familial cancer syndrome. Our observations exclude MLK-3 as the MEN1 gene. Received: 25 September 1996 / Revised: 16 December 1996  相似文献   
4.
5.
6.
7.
Hao  Qing  Liu  Xiaoguang  Zhao  Guozhong  Jiang  Lu  Li  Ming  Zeng  Bin 《Biotechnology letters》2016,38(3):519-525
Biotechnology Letters - To characterize biochemically the lipid metabolism-regulating acyl-CoA binding protein (ACBP) from the industrially-important fungus Aspergillus oryzae. A full-length cDNA...  相似文献   
8.
Kandelia candel is an important mangrove tree species of family Rhizophoraceae. Here we isolated eight codominant compound microsatellite simple sequence repeat (SSR) loci from K. candel. Our isolated loci provided compound SSR markers with polymorphism of three to 11 alleles per locus. The expected and observed heterozygosities ranged from 0.230 to 0.887 and from 0.083 to 1.00, respectively. These markers would be the useful tools for analysing questions concerning population genetic structure and mating system of K. candel.  相似文献   
9.
We developed eight polymorphic microsatellite markers from the Sachalin fir (Abies sachalinensis Masters). The number of alleles per locus ranged from eight to 31, with an average of 21.4. The observed and expected heterozygosities ranged from 0.656 to 0.937 and from 0.710 to 0.945, respectively. These markers will be available for population genetic studies and parentage analysis.  相似文献   
10.
Many animals exhibit different behaviors in different seasons. The photoperiod can have effects on migration, breeding, fur growth, and other processes. The cyclic growth of the fur and feathers of some species of mammals and birds, respectively, is stimulated by the photoperiod as a result of hormone-dependent regulation of the nervous system. To further examine this phenomenon, we evaluated the Arbas Cashmere goat (Capra hircus), a species that is often used in this type of research. The goats were exposed to an experimentally controlled short photoperiod to study the regulation of cyclic cashmere growth. Exposure to a short photoperiod extended the anagen phase of the Cashmere goat hair follicle to increase cashmere production. Assessments of tissue sections indicated that the short photoperiod significantly induced cashmere growth. This conclusion was supported by a comparison of the differences in gene expression between the short photoperiod and natural conditions using gene chip technology. Using the gene chip data, we identified genes that showed altered expression under the short photoperiod compared to natural conditions, and these genes were found to be involved in the biological processes of hair follicle growth, structural composition of the hair follicle, and the morphogenesis of the surrounding skin appendages. Knowledge about differences in the expression of these genes as well as their functions and periodic regulation patterns increases our understanding of Cashmere goat hair follicle growth. This study also provides preliminary data that may be useful for the development of an artificial method to improve cashmere production by controlling the light cycle, which has practical significance for livestock breeding.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号